ABSTRACT BACKGROUND: The quality of life (QoL) construct has also contributed to understanding the comprehension of factors involved in the existence of people infected by the HIV/AIDS. The objective of this study is to assess the quality of life (QoL) of people with HIV/AIDS (PLWHA) in Wonogiri District, Indonesia.  METHODS: A cross-sectional study was conducted from September to November 2017. Convenience samplingmethod was employed to recruit 39 people living with HIV/AIDS (PLWHA) at Voluntary Counselling and Testing (VCT) of Wonogiri, Indonesia. Research datawere collected using a self-administered questionnaireof WHOQOL-HIV BREF. The data werefurther analysed using a t-test and a Chi-square test, while linear regression was used to evaluate factors that correlatewith the PLWHAs’ quality of life. RESULTS: The results showed that the gross mean score of social relationships domain is 13.59;psychological domain is 13.31; environment domain is 13.28; spiritual/personal beliefs domainis 13.15; physical domain is 13.10; and level of independence domain is 13.77. The symptom of HIV is associated with quality of life (B = 7.611, β = 0.362, t = 2,046, p value = 0.049). CONCLUSION: Healthcare provider should increase provider-initiated testing and counselling(PITC) to contracting group, high risk group, susceptible group, and the community. The PLWHA are recommended to actively participate in peer support groups (PSGs) so that they can improve their quality of life.KEYWORDS: Quality of Life; PLWHA; WHOQOL-HIV BREF; HIV/AIDS; VCT