BACKGROUND:Physicians working in Saudi Arabia belong to different countries and may have differences in knowledge and attitude towards psychiatry. We evaluated non-psychiatric physician’s knowledge and attitude towards psychiatric disorders, such as anxiety and depression, in the Kingdom of Saudi Arabia.METHODS: A descriptive cross-sectional study design was used. The current knowledge and attitude towards anxiety and depression of physicians were determined by using a questionnaire. We distributed 180 study questionnaires at various hospitals to be answered by physicians in the Riyadh Province of Saudi Arabia. One hundred and forty-two completed questionnaires were included in the study. The participants were divided into three groups: (1) 63(44.4%) general practitioners (GPs), (2) 55 (38.7%) specialists and (3) 24 (16.9%) family practitioners. Data were analysed using the chi-square, ANOVA and independent sample t-test.RESULTS: GPs and specialists showed a negative attitude towards psychiatric patients, but family practitioners showed a positive attitude. There were statistically significant differences (p˂0.05) in the knowledge regarding anxiety and depression among the groups. The relationship between specialty and knowledge was statistically significant (p˂0.05) and the effect of first language is insignificant (p>0.05).CONCLUSION: Expansive enlightenment programmes, continued medical education and inclusion of psychiatric posting in rotating residential internship programme during undergraduate courses are required for physicians not only to fill the gap in knowledge and attitude but also to improve their cognitive, communication and interpersonal skills.KEYWORDS: GPS, family doctors specialist, survey, mental health, anxiety, depression, knowledge and attitude.